Allopurinol
Allopurinol

0.76
Reduces the frequency of gout-related joint discomfort for Pain Management by inhibiting xanthine oxidase to lower systemic uric acid synthesis.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | Trackable (5-9 days)
Shipped in a discreet, unmarked envelope with all required documents enclosed.

Product Sheet

Active Ingredient(s)
Allopurinol
Reference Brand
Allopurinol
Product Origin
Generic Product
Reference Manufacturer
Mutual Pharmaceutical
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Gout Management
Product Category
Xanthine Oxidase Inhibitor
Pharmacological Class
Antihyperuricemic
Clinical Indications
High uric acid levels, gout prophylaxis
Manufacturer Description
This medicine is utilized to manage uric acid production, indicated to mitigate the frequency of gouty arthritis symptoms.
Mechanism of Action
It acts by reducing the body's overproduction of uric acid. By inhibiting the enzyme responsible for final urate synthesis, it lowers serum and urinary acid levels.
Route of Administration
Oral
Onset Time
2–6 hours
Duration
18–30 hours
Contraindications
Acute gout flare, severe hypersensitivity
Severe Adverse Events
Severe skin reaction (Stevens-Johnson Syndrome), liver dysfunction
Common Side Effects
Mild rash
Uncommon Side Effects
Nausea, diarrhea
Drug Interactions
Azathioprine, Mercaptopurine
Pregnancy Safety Warnings
Consult a healthcare professional for necessity.
Storage Guidelines
Store at room temperature below 30°C.
Related Products
Febuxostat

Allopurinol FAQ

What does bioequivalence mean for allopurinol?

Bioequivalence indicates that a generic allopurinol product delivers the same rate and extent of absorption as the reference formulation, ensuring comparable plasma concentrations under identical conditions.

Why is allopurinol more accessible through multiple manufacturers?

Manufacturing scale and supply diversity allow several WHO-GMP-certified facilities to produce the compound, reducing reliance on a single source and facilitating broader distribution.

How do multiple manufacturers support the supply network?

Having several producers creates redundancy, mitigates potential disruptions, and enables the logistics platform to source from the most readily available inventory.

Will the appearance of allopurinol tablets vary between batches?

Tablet colour, shape, and imprint may differ across manufacturers or production runs, though each batch conforms to the same pharmacopoeial specifications.

What storage conditions preserve allopurinol stability?

Keeping tablets at 20 °C-25 °C, away from moisture and direct light, maintains chemical integrity throughout the labelled shelf life.

What personal-use import rules apply for allopurinol in Singapore?

Travelers may bring a limited supply for personal use, subject to HSA-defined quantity thresholds; always verify the current limits directly with the HSA as regulations may change.

Is allopurinol screened for in standard drug-testing panels?

Allopurinol is not typically included in routine workplace drug-testing panels; detection methods focus on substances with abuse potential, though specialized testing can identify its metabolites if required.

Clinical Identity & Compound Overview

Patients experiencing gout-related discomfort often require a medication that limits uric acid production. Allopurinol - available as a 300 mg oral pill - provides the standard concentration used in chronic management. The tablet form is manufactured in multiple strengths, but 300 mg remains the common prescription dose for routine therapy.

Biological Mechanism of Action

Allopurinol exerts its effect by inhibiting xanthine oxidase (the enzyme that converts hypoxanthine and xanthine into uric acid). This blockade reduces the formation of uric acid, thereby lowering serum concentrations that can precipitate gout crystals. The drug is metabolised to oxypurinol, which continues to inhibit the same enzyme throughout its longer half-life.

Regulatory Recognition & Clinical Indications

The active ingredient allopurinol is recognised by Singapore’s Health Sciences Authority (HSA) as a therapeutic agent indicated for the long-term management of hyperuricaemia associated with gout. It serves as a standard intervention for reducing uric acid levels in patients with recurrent gout attacks.

Absolute Contraindications & Safety Warnings

Known hypersensitivity to allopurinol

Individuals with a documented allergy to allopurinol should avoid use and seek professional guidance.

Severe renal impairment

Patients with markedly reduced kidney function are at heightened risk of accumulation and should be evaluated by a physician before any exposure.

All dosing, frequency, duration, and escalation decisions are determined exclusively by a supervising physician.

Adverse Events & Drug Interactions

Common Reactions

  • Rash (skin redness that may appear shortly after initiation)
  • Gastro-intestinal upset (nausea, diarrhoea)

Less Common Reactions

  • Elevated liver enzymes (indicating hepatic stress)
  • Mild dizziness (transient light-headedness)

Serious Events

  • Severe cutaneous adverse reactions such as Stevens-Johnson syndrome (life-threatening skin eruption)
  • Toxic epidermal necrolysis (extensive skin detachment)

Drug Interactions

  • Azathioprine (increased cytotoxicity)
  • Theophylline (reduced clearance, potential toxicity)
  • Warfarin (possible elevation of INR, affecting clotting)

Administration Guidelines

Allopurinol tablets are taken orally and should be swallowed whole with an adequate amount of water. The medication can be administered with or without meals, and all decisions regarding dosing schedules rest with the patient’s physician.

Storage & Handling

Store the tablets at controlled room temperature, ideally between 20 °C and 25 °C, protected from excessive moisture and direct sunlight. Shelf-life information is provided on the packaging; expired or unused tablets must be disposed of in accordance with Singapore’s local pharmaceutical waste regulations.

Supply Access & Platform Role

The generic formulation of allopurinol is sourced from manufacturers such as Teva, Cipla, and Sun Pharma, with the platform acting solely as an international logistics intermediary. All products are supplied through WHO-GMP compliant channels, and verified manufacturers are listed for transparency. Confirmed orders are redirected to an external third-party payment processor.

Medication-Specific Glossary

Allopurinol
A purine-analogue drug that inhibits the enzyme responsible for uric acid synthesis.
Xanthine oxidase
The enzyme that catalyses the oxidation of hypoxanthine to xanthine and then to uric acid.
Oxypurinol
The primary metabolite of allopurinol that retains enzyme-inhibitory activity.
Purine metabolism
The biochemical pathway by which nucleic acid building blocks are synthesized and broken down, culminating in uric acid production.

The information presented herein is for educational purposes only and does not constitute medical advice. This platform functions exclusively as a brokerage intermediary and does not operate as a pharmacy. No clinical recommendations are offered; readers should consult a qualified physician and review the accompanying product insert. Importation of allopurinol into Singapore must comply with HSA regulations, and users bear full responsibility for adhering to those legal requirements.

Information associated with Allopurinol is curated and periodically reviewed using established medical references and prescribing guidelines. Content is intended for general awareness and should be verified with a licensed healthcare professional before use.
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